I would start with small steps then work your way up the ladder. Why don't you work part-time or volunteer first? If you can handle this, add more responsibilities. I have not worked full-time in about 8 years but am working at two part-time jobs and doing free-lance as well. I am doing ok. I am seeking full-time positions now because I want to see if I can do it. But, the older one becomes these positions become more scarce. I know how you feel about your situation and believe you should not set yourself up for failure by pursuing a full-time job if you have not worked in awhile. I again would start with a part-time job then if you can do this successfully add more hours then seek full-time work.