Alprazolam/Xanax has been my go to medication for panic disorde for about 3 years now. Started with 1/2 mg, now at 1mg.

Usually I just google these kind of questions, but I can't find an explanation and am genuinely curious and was just wondering, maybe some of you more science savy/ med educated people here might know...

It didn't matter the dose - Lorazepam either did NOT work on me whatsoever - no effect OR twice - it gave me a very very negative effect, exasperating my anxiety, very shortly after ingestion to the point of having my worst extreme episodes of panic and fear and terror - once putting me in the hospital - my only time in a mental hospital.

Why? What is so different about me or it that it would do that?? I am just SO curious....

is it metabolism?
is it some kind of brain chemical reaction?

1mg xanax is doing great for me for now, but I definitely want a back up plan for the future because I don't want to go back to my major panic disorder/agoraphobic state without meds and I don't really want to have to up the dose if 1 mg becomes ineffective at some point and I DEFINITELY don't want to go through again what I went through with the lorazepam