15 years ago When I was newly diagnosed I was in a clinical trial for rapid cyclers. They'd proven previously that depakote and lithium together were more beneficial for something (I'm pretty sure rapid cycling but not enough on the depressed side?) so they were using that combo with lamictal to try to help the depression.

I don't know what the results were which makes me think it didn't work. I've tried to find publications of the study and never did and I was hospitalized with someone who did the same trial and she'd never heard anything or found publication either.

For what it is worth it did not work for me but since we couldn't get a therapeutic depakote level it wasn't really fully attempted for me. I did much better with the same combination once depakote ER came out but I don't think I was only on the 3 drugs then; I was onto a 4th mood stabilizer soon after ending the trial.