I'm on Lexapro and I can't say much because it's the only anti-depressant I've been on .. it made me extremely manic at first because the doctor didn't think I had Bipolar but after a few days of being on it my energy levels skyrocketed. So finally they tried me on it with other meds and it hasn't necessarily helped my depression but my pdoc doesn't seem to want to try anything else. I'm going to be talking to him about possibly changing it when I go on the 22nd to see him.. maybe I need a different one. Cause it sure doesn't seem to fit the bill for me. It doesn't make me worse with other meds mixed in .. but it doesn't help either ..