I have been on lithium for over a year now, 1500mg was the highest I had to lower the dose to 900mg because I had the shakes (tremors)more then I could handle. My Pdoc added Lamictal and we are slowly adding our way up 300mg (I am at 225mg) He thinks 300mg may work. So far so good, I still have my 'manic friend' haunting me but not as bad as before. I am also on 600mg of seroquel. And Xanax, provigil, ativan and klonopin, as needed. My cabinet looks like a drug store! Only time will tell if THIS coctail will be the one. Good luck, I have heard lots of people do well with both the lithium and the lamictal.