It's entirely dependent on your response. Absolutely no way to tell without trying. Genesight genetic profile testing or something can be used to help predict medicine responses, but again, those predictions are just guesses and advice based on your body (so how you truly respond is entirely unique to you and you alone). Side effect rates tend to go up with higher doses and down with lower, but this doesn't hold true for everyone either. It's just a general rule I've "heard."