A few of my evening meds could be considered sedating, but I think the only one that really is that I take is Seroquel XR. Though it certainly helps with my sleep, at my dose it also helps curb mania and depression. I appreciate Seroquel XR, but I need to take it early at night and try to go to sleep at a reasonable time, otherwise it's hard to get up in the morning with the alarm clock. If I force myself awake with too little sleep after taking Seroquel XR I get what I call the Seroquel XR "hangover". Basically that makes me very irritable and spaced out and clumsy. Kind of like trying to drag a 3 year old out of bed at 4 am.