No, it sounds like a paradoxical effect, which is odd considering that a lower dose didn't affect you that way. I take 50mg and it works for me. I do get hangovers but not every day; it's worth it for the sleep. Would your doctor let you go back to the 25mg (if their affect hasn't also changed) and add something? I get Lunesta 3mg in addition to the Seroquel. It may seem like a lot, but good sleep is so important for bipolar.