I tried Wellbutrin twice and though I know it's not supposed to work until a month or so I got really depressed right away. Both times I quit and felt better. The third time I tried it I waited a month or so and it really helped when I got to 300mg.

At first I was very irritable when it kicked in but I dropped back down to 150mg. When I got back up that had gone away. I love it; I think it really does help (even prevent) depression. I'm on 450mg which is the highest safe dose (any higher and the seizure threshold is just too low). I don't know that 450mg is really that much better than 300mg.