Years ago I took 450mg of WB and it helped a lot. I don’t remember why I stopped, but it was for at least five years. Last year I tried to go back on to treat some mild depression. Started at 150mg XL,
and almost immediately entered a mixed episode (without realizing it in the moment). Tried to stick it out, talked with my doc a few times. After a couple weeks we moved to 100mg SR. After about a week of that I was seriously contemplating hanging myself in the back shed. I quit taking it and after about four days it left my system and I was fine.

No idea why it worked before at a high dose, then turned on me years later.....but I’ll never swallow the stuff again. Ranks right up there with the worst three weeks of my life.

It’s not for everyone.