I have and am now taking Buproprion. I have taken it at a high dose. I never had any problems with this med. This AD has in the past pulled me out of a bad depression. I think the reason I have had no problem with this med is in part that I always use a AP with it which helps. I do know of one well recognized pdoc that places patients on a mood stabilizer first instead of an AD. I do not know why, but this seems to work for his patients. Perhaps if this did not work, he may use an AD. I do not know, but this seems logical to me.