I guess this all goes to show that Your Mileage Will Vary.

I'm rapid-cycle BP2. I take 450mg bupropion XL but was already at 300mg lamotrigine when I started taking it. Helps me tons. Made me a little hypo at first, but it settled down.

From what everyone else is saying, perhaps I should have been more cautious when starting it, perhaps I just got lucky, perhaps I have the right genetics, or perhaps it's mostly those of us who've had ****** experiences who feel disproportionately motivated to write in with warnings. Idk.

All in all it sounds like the smartest thing is to closely monitor oneself given the possibility that it can cause mania, but by no means to reject it since it can also bring significant relief.