Yes, I'm trying subutex for severe refractory depression. It seems to be helping. Yes, the first week, my symptoms seemed gone! Now after 4 months, I'm still struggling with the dosage. I asked if tolerance is a problem and he said, "No one knows, but yes." He said the effective dose is 2-8 mg. As I am opiate niave, I have only just now worked myself up to 1.5 mg. So, maybe my dose is just still too low to maintain steady levels.

Are you still doing well? Please check in.