Wycelf - I do know that there are several longterm studies involving Prozac™ (fluoxetine), that have shown (so far), no obvious adverse health effects. I am not aware of any involving other SSRIs, but I am sure that there are some in progress. I have not had any brought to my attention recently.

A few years ago I did read a few sudies involving the longterm use of the older tricyclic antidepressants (TCAs) like Elavil™ (amitriptyline) and Tofranil™ (imipramine). These antidepressants have been on the market since the late 1950s. Generally, there have been no remarkable problems associated with the longterm use of these agents.

Sorry that I am not of much help on this. - Cam