I believe it can.

There's elevation level, pollution level, barometric pressure, degree of sunlight, humidity, to name a few. People, level of congestion, stress, quality of life, cost, and more.

In your case, I would think LA (as in Los Angeles) would have negative pollution effects, but there are so many factors. Or are referring to Louisiana? I do know of people who say the humidity really affects them. Where I live affects me a great deal too; but although I am aware of some reasons, it all doesn't fit--I haven't figured out exactly why.