Not as of yet. My therapist told me that some of his clients have that side-effect but it hasn't happened to me. I am on a 100mg currently. My pdoc started me on 25mg, gradually moved it to 50mg, and I requested he make the jump up to 100mg so I could get a handle on my sleep.

My advice, (if you feel yourself gaining weight), is eat at the around the same time every day, (or at least try to), and avoid the weight gainers like soda, sweets, junk food, etc. I am not exactly skinny but I haven't gained any weight since changing over to the Seroquel and I think that's because I have maintained a regular eating schedule, and I also try to eat healthy.

Good luck with the Seroquel if you're on it. It really helped me!

I am hanging tight in the middle, but swinging round to high because I am in a really good mood.