No, Depakote actually seemed to keep me depressed. It, along with the antipsychotic Invega, actually extinguished a bad mania I had that hospitalized me. I have been manic on other bipolar meds/cocktails like Lamictal, Abilify, Trileptal, Neurontin, Lithium, Geodon, and more. Basically, sometimes I've just had breakthrough mania that required dose adjustments or medication changes. That's life with bipolar sometimes.

So you know, when I took Depakote I took about 1200 mg per day. I'm a woman. You must know that Depakote has therapeutic levels. That was the dose I needed for therapeutic level for me. Have you ever had blood tests to determine yours? The doses we need to have a therapeutic level varies. Again, I took it with an antipsychotic, too (Invega).