Sounds like side effects should be secondary to your health. Seroquel takes time to work (up to a week), but it helps with sleep almost instantly. Talk to your Pdoc about the XR formulation, as the effects are much less than the instant release formulation.

As for Depakote, if you are experiencing mania through a high dose, it sounds like you either need a secondary medication or a complete change in your regimen.

Have you thought about a short term hospitalization for a medication change?