I'm thinking of asking my doctor to put me on Seroquel. I've taken it before but I got my self off it because I was scared of the side effects. I'm not sure if I can put it together with depekote or not. Can certain meds like depekote make you feel mania though if your on a high dose? I never had that problem before when I was on a low dose. I know when I was on Rispridone it made my mania worse. Made me feel like a psychopath so I immediately got my self off it and felt better.