Both my husband and I were pretty open from the get-go. He has MS (and depression related to it), and I have my handbasket of MI diagnoses and medical nuisances. He's typically concerned about what mood I'm in. His second most-used phrase (besides "I love you" of course) is "Are we cool?" If I'm withdrawing he's going to ask about it. I may be annoyed by it at times, but I know his heart is in the right place. We've talked a lot about our conditions and things to look for. We have a numbering system of 0 to 5 for our moods.