I've been on Zyprexa for four years now, and even so I managed to lose 100 lbs over the course of a year. I lost my husband and my appetite in 2016, and I still can't eat as much as I used to. The weight loss has stopped, but I don't think Zyprexa has anything to do with it. It's funny, the first time I went on Vitamin Z back in 2012 I gained 25 lbs in only two months, but when I went on it full-time in 2014 I didn't gain anything. I guess it just depends on how one's metabolism works.