I've been on Metformin with clozapine to help control the weight gain. It stopped when I started the metformin about 6 months into the clozapine and before my gall bladder went nuts and I was too sick to be on a diet I had lost every pound gained on clozapine and 10 more from the meds before it. I'm not diabetic although with my family history and the meds am high risk.