I have been depressed to greater or lesser extent most of my life. Effexor has been a miracle for me. It took a long time (over 2 years) to get the right med and the right timetable to take it (2ce a day to avoid tremors with a single higher dose), but it was worth it.

I dread the day that it may stop working. Hopefully, there will be new generation of medication out there.

I practiced positive thinking for over 20 years. Yes, it helped. And cognitive behavioral therapy and prayer and the support of my friends and the forum helps. It has to be a multi-pronged approach for me.

Best wishes for feeling better and saving your marriage.