Decades after still going, and though much better, not nearly as bad as it once was. I credit partly to yoga and exercise. I'm the side effect king though. I've gotten the black box checked off on most meds so far. Doctors know this before I allow them to give me anything and I make them go over everything with me. Most are really happy to do so. I have only a couple meds left for infections and I'm on the last of the mood stabilizers that are anti-siezure drugs. Pain meds don't work in my body and I've got some food allergies too.