I take 200mg Lamictal. I suppose it helps my depression. My doctor wanted me to stay on it even with a full dose of antipsychotic (Latuda) just because of the extra mood stabilization it gave me. You should know that, though it's good for depression, it's a weak ant-manic. If you're prone to serious mania you should also be on an effective antipsychotic (or other mood stablilizer; I'm assuming you're just on Seroquel at a low dose for sleep.). Nice thing about it is it's low side effect profile.

I take it all in the morning, but since it doesn't either energize me or make me sleepy it doesn't matter when I take it.