I've been taking 400mg (2x200 mg pills) for a couple of years now. I did notice it lifted my depression and made my "normal/stable" periods longer. I don't think it really helped with the mania as much though, I take an ap for that.

As for when to take it, I take both at night. It doesn't make me tired or my stomach upset. Because I don't get any side effects the doc said I can take them together whenever I wanted it. I always forgot taking them in the morning cuz I'm always in a rush in the morning so I decided to take them at night when I'm more relaxed. My doc said if I get extra tired and have trouble waking up or they upset my stomach to take one in the morning and one at night.