I’ve been on 300 mg of Seroquel for awhile now. It has helped me with the manic symptoms and usually causes me to fall asleep without a problem (unless I am manic). Everyone is different, but I have not gained weight on it. I do tend to be an avid outdoor walker/jogger though, so I exercise regularly. I never noticed it increasing my appetite. My pdoc first tried me on the extended release version, and that made me want to sleep all day. I hope it continues to work for you!