(1) high cholesterol
(2) chronic fatigue
(3) suicidal thoughts
(4) severe depression at high enough dose

Literally, the WORST depression I have ever had in my entire life came from 300mg of seroquel XR. I don't know how or why, but it did. This was confirmed by going off it and seeing the depression go away almost immediately. So please, please, PLEASE say something if your depression ends up getting worse. It happened to me and happened to someone else on the forum I know.