Hello kp: I see this is your first post here on PC. So... welcome to PsychCentral!

I don't know, of course, if you're simply here seeking advice with regard to this particular concern or if you plan to hang in here with us.

However should you be planning to continue on, may I suggest you introduce yourself to the general membership over on our New Members Introductions forum? Here's a link:
https://forums.psychcentral.com/new-...introductions/
One forum that may be of particular interest to you would be the relationships & communication forum:
https://forums.psychcentral.com/rela...communication/
Another would be the depression forum:
https://forums.psychcentral.com/depression/
And a third might be the partners & caregivers support forum:
https://forums.psychcentral.com/part...ivers-support/
There's also a forum dedicated to anxiety:
https://forums.psychcentral.com/anxiety-panic-phobias/
I'm certainly no expert with regard to the impact of depression & anxiety on romantic relationships.

But my thinking, with regard to your concern, is that certainly your friend's depression & anxiety could be having a significant impact on how she feels about both you in particular as well as the relationship the two of you have in general.

When a person is struggling with depression & anxiety it is so difficult to sustain any kind of interest in, or enthusiasm for, anything at all... including romance.

The problem is, at least from my perspective, under the circumstances you describe there's no way to know for certain if you friend's interest in you has simply waned or if this is all just a symptom of her mental health issues.
You didn't mention, in your post, if your friend is receiving any mental health services... if she sees a therapist & / or if she's on antidepressant medication. From what you describe, my personal opinion would be that she may be in serious need of these services just for herself. But in addition, unless & until she gets professional help for her issues, there may be no way for either her or you to really sort out if there is in fact a future for the two of you together. If your friend is denying that she has mental health issues & is refusing to seek treatment, this in-&-of itself may be a sign that this is a relationship you simply cannot sustain no matter how much you may wish to.
Here are links to some articles, from PsychCentral's archives, that hopefully may be of some help in your efforts to sort out what is happening & what, if anything, you can do:
https://psychcentral.com/blog/depres...hy-in-couples/
https://psychcentral.com/blog/how-de...at-you-can-do/
https://blogs.psychcentral.com/welln...-relationship/
https://psychcentral.com/lib/how-can...hos-depressed/
https://psychcentral.com/blog/10-thi...sed-loved-one/
https://psychcentral.com/blog/6-thin...hos-depressed/
https://psychcentral.com/blog/how-to...ression/?all=1
https://psychcentral.com/blog/11-way...-denial/?all=1
My best wishes to you both...