Everyone is different of course but I started having improvements several weeks in. I don't remember exactly how we did the dosing but think I went to 300XR + 100 regular the second or third week. Big-time improvement.
Tweaked dose some as I was still having some cycling. Winter was some rough times and upped dose more. Cleared up some (no doubt partly from Spring, as everyone does), then basically was over-sedated and stuck in a fog. Pulling back some now the last couple months and I'm doing everything I can behaviorally to help myself.