This is interesting. I do not think depression is a side effect of Olanzapine. Oh well. It took several weeks for me to benefit from Fluoxetine. Unlike some APs that have a relatively immediate effect, as you know, this is not the case with ADs. The combination of Olanzapine and Fluoxetine worked very well for me. The Olanzapine is one of the more powerful APs. I find that it also strengthens the effect of the AD. It is an FDA approved combo for BP. However, eventually my pdoc added in Buproprion which made a difference. The Olanzapine did make me just a little “drugged” which is not good for driving a car. My concern with Olanzapine was ending up prediabetic.