The one that helped me the most and most concistently has been Adderall XR which of course isn't technically an antidepressant but it works for me. I have been lucky that I haven't developed a lot of tolerance for it and have responded to very small amounts -10 mg a day. I have taken it for several years.

Previously I have had pretty good results with Prozac at first but it eventually led to overwhelming apathy and I discontinued it. Effexor worked pretty well on my anxiety and somewhat on my depression but I discontinued it after it caused memory problems. St Johnswort worked really well for me for about a year. I discontinued it and the second time I tried it have not had the same good results.

I have had trials of many other drugs but those worked the best.