I have been on Zoloft and Depakote for many years but I can tell that the Zoloft has lost its efficacy for me.

My pdoc has now prescribed Cymbalta to replace the Zoloft. I am on day 5 of 30 mg. I will be on Cymbalta 2 weeks - then a titration to 60 mg.

I tend to be very susceptible to suggestion so I have purposely not read the side effects. (pdoc said to be careful of possible constipation) Glad to read this thread and thank you all for the feedback.