AD stopped working, I have taken almost every AD out the. Dr recommended PRISTIQ (GENERIC VERSION). I have been taking about two months. It has added a new level of agitation and anger that has embarrassed me as at the time it seems I have no controll over it. I am going to discuss with PDoc next visit. Anybody else have this with Pristiq? Meds: 800 mg Seroquel, 2mg Klonopin, Temazepam, Cogentin, Gabapentin and recently added Pristiq. I think also the Pristiq has brought back some Paranoia also... I am ready to give up on AD'S as they all seem to be dead ends or complicate things. I am so tired of this.