Sharita - It seems that almost everyone goes through a "very irritable" stage when starting Wellbutrin SR™ (bupropion). I remember that when I first started taking it, I would look for reasons to be mad at people. For most people, the irritability seems to be at it's worst at approximately 4 weeks after starting the medication, but does seem to disappear by the 6th week.

I found that as long as one realizes that it is the Wellbutrin causing the irritability, and tells those close to them that this side effect will go away by week 6, one can take measures to minimize the "damage" the irritability can cause. When you feel the anger rise in you, remove yourself from the situation; go be by yourself and tell yourself it is the medication. Then try to rationalize the anger, and calm yourself down before facing the world again.

Tell those close to you that you may say things that you don't mean, and that it is the drug talking. Also make sure that you remind them (and yourself) that you will not always be like this while taking the drug. Think of the irritability as a very annoying start-up side effect. At the time it may not seem like the irritability will end, but it does in a vast majority of people starting this medication.

I hope that this is of some help. - Cam