I took Celexa after Zoloft and while taking an antipsychotic medication. I gained weight with all medications. I stopped taking Celexa after becoming diagnosed with mania. I was then started on Depakote which was really bad for me in terms of side effects. All in all, I started anti-depressants because of extreme depression after taking risperdal. Then, I started to get manic then was taken off them. I don't know which medication caused me the most weight gain but know that I gained much weight from taking medications in general.