Thanks all for your replies. I was hoping I wasn't the only one who has experienced this. Since it's satuday, and can't call the doc, I called my local crisis line as I am deeply concerned about this "hangover" feeling today since the manic episode yesterday. All they could say was to talk to the Pharmacist or call the ER to talk to them about whether the Neurontin caused this or not. So, as I went to pick up a script for my thyroid issue, I inquired of the Lexapro/ Neurontin and whether they have had anything to do with the crap I am dealing with today. She told me, the low dose of Neurontin could not have caused the manic episode, that it was just part of my illness and now I am finding myself very agitated and unintentionally being short with my kids. I am so tired of this flip-flopping around. I have to get this under control, and now extreme anxiety is kicking in. UGH!!!!!!!!!! My husband, bless his heart is doing his best to be encouraging and supportive, but it is wearing on him and he's begininning to think all this stuff is a bunch of hog wash and that the doc's are screwing my head up even worse than it was before. I just want to lay down and disappear...…