I can only speak for myself but I don't know how one avoids difficult people completely. Sometimes the best thing you can do is just cope with the ones around you. If your boss is difficult but you really need the job or maybe even you really like the job, you should cope with the boss. If a family member is difficult, there aren't many good options. People do cut family members out of their lives or they just move away, but I'm not a fan of either.

Respect is very important. Good manners matter. What can you do but try your best and hope things go your way?