Hello axelrose and welcome to PC! I've heard of people taking 500mg of Seroquel, so I don't think that 400mg is too much. I've only been on it for a couple of months, but it seems to be working wondefully for me. I am concerned about the possiblity of weight gain because I was on steroids for an extended period of time a few years back and put on 80lbs in about a month, so I really cannot put on anymore. I'm already physically uncomfortable.