I was on 120 mg. of Cymbalta for a year or two. I decided to go off when my health insurance changed & my out-of-pocket cost skyrocketed! I went in to see my pdoc about it & he suggested a reduction schedule that took me off over the course of 2 weeks. I thought this was very fast. But, since that was what he recommended, I went with it. And I don't recall ever having any serious issues. I haven't taken anything since then.