Yes! When I first started having bad bipolar symptoms, a regular dr. (i.e. not pdoc) said I had PMDD (bad PMS) and prescribed double my normal Celexa. That threw me into a manic episode that lasted quite a while, followed by a depression where I was actually looking up ways to kill myself. (Spare the details as it might trigger.) Even then, it was only suspected that I was bipolar, even though I was given Depakote. Now I am confirmed Bipolar I with mixed episodes.