I would go with MyBestKids and others who have had ECT, what they have to say. I understand you feel that your doctor might be getting frustrated but I don't think he actually is I think it's just that since you've tried so many things and they have not worked it is getting down to choices for treatment-resistant depression. I'm glad you know your doctor well and have had a relationship with him and his office staff and a therapist for so long. It can be so much harder when people go from doctor to doctor and don't have enough of a relationship with anyone to have anyone they feel they can talk to. I'm glad the nurse is less scary so you could ask her what's going on. You are doing everything fine, the doctor is not mad or frustrated at you, just the darn old depression! I hope you all find a good next step for you.