Ive been on 400mg up to 800mg. for 2 years and have gain 60 pounds most meds of this types seem to make you gain weight .As a inside joke at the groups I go to having a med. belly is how you tell who is on or off their meds.The trick is to find the right amount for you and the weight gain will stop or even go down abit between 300mg and 400mg was mine.