The last time I revised my resume, I discovered that there are other ways to set up a resume that don't highlight dates of employment-basically focus on skills, ethos and strengths. Another way to address it ahead of time is in the Cover Letter.

And in an interview focus on time out of the career force was something that was resolved and won't be an issue going forward while focusing on that you had done at your last place of employment.

Lots of people have had breaks in employment in this day and age. Unemployment, caregiving for elderly parents, starting families, dealing with personal or family health issues. Etc.

Of course it's a nerve wracking topic at the same time downplaying it as much as possible during an interview will give the impression that it's behind you.