Like the others I'm on synthroid from lithium and I don't really care. I've been on it a long time and don't even think about it now. I've been off lithium for years and still need it but I've also had 3 toxicities so that might have set my fate in stone. I don't know if going off lithium can stop the hypothyroidism after it is there.

Weight loss is possible. I've lost 25 lbs while taking clozaril (with metformin to help) so I've come to believe that it can be very difficult to lose weight but with the right diet and exercise and support system at least some loss is possible regardless of the meds we've been on or are on currently. It's not easy or guaranteed but it's possible.