I experienced one of my worst manias after being on Abilify for about 3 months. I must also mention that at the time I was also on Lamictal, which after a number of trials clearly showed was activating for me. The question is, was it solely the Lamictal that made me gradually full blown manic with psychosis, with Abilify just being ineffective at preventing mania? Or were both activating? I don't know the answer. In any case, I have never taken Abilify since, which also gave me akathisia. I am taking a small dose 100 mg of Lamictal, but with a large dose of Tegretol XR and Seroquel XR. My psychiatrist never increases my Lamictal dose beyond 100 mg. I've taken that low dose with Tegretol XR and Seroquel XR for about 8 years now.