Reading the forums used by psychs and pdocs, many believe that Buproprion is contraindicated for bipolar. I have been on a high dose of it in the past, but I was on an AP too. I may be just tolerant of it more than other people are. I may be lucky I did not go manic. I do not know. Then aphetamine salts (Adderal) was added. Then levothyroxine was added. That did the trick. Then I was taken off all of that over time. Now years later I am back on a dose of Buproprion.