I use Emsam, which is an MAOI. It works really well for me and I'm bipolar so that's a hard thing to find. There are food and drug restrictions at certain doses but it is easy to get used to those. When nothing else works MAOIs are great and Emsam is a patch which makes it less difficult with restrictions since it is not digested with foods so it is the easiest MAOI as far as I am concerned.