I have been taking 100 mg of Lamictal for the last 7+ years in addition to other bipolar medications. I take it in the morning and it's just fine. Lamictal can be activating for me, but my other medications keep that in check. My evening meds, that include Seroquel XR, are much more sedating than my morning meds. In the morning, I take 600 mg Tegretol XR, the 100 mg Lamictal, a small dose Propranolol, Synthroid, and Ativan. Very often by midday my mood spikes up a bit, but my evening meds (that don't include Lamictal) calm that.