I have been on both regular release and extended release Seroquel and never had that side effect happen to me. The ER version makes me too tired throughout the day, the regular version just knocks me out at night and helps with the mania, but you are on a high dose too...maybe too high? If you've had that happen since you started Seroquel and nothing else has changed, I'd give your pdoc a call and not wait it out another 2 weeks. Pdoc (both old and new) have always checked me for hand and tongue tremors while on Seroquel though.